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Heart Disease Leading Cause of Death Worldwide

Diane | September 19, 2008
Resource:  America.gov:

Global research projects seek to end preventable heart attacks, strokes

By Erika Gebel
Special Correspondent

Washington — Despite dramatic medical advances over the past 50 years, heart disease remains a leading cause of death globally and the Number 1 cause of death in the United States.

Heart disease, or cardiovascular disease, accounts for 30 percent of deaths worldwide, according to the World Health Organization (WHO). In the United States, almost 700,000 people die from heart disease each year. In 2006, the American Heart Association estimated heart disease would cost Americans more than $258 billion.

Heart disease encompasses several specific heart ailments. One of the most common is coronary heart disease, which accounted for 71 percent of U.S. heart disease fatalities in 2002 according to the Centers for Disease Control and Prevention (CDC). Other common cardiovascular diseases are congenital heart disease, congestive heart failure, pulmonary heart disease and rheumatic heart disease.

Coronary heart disease is caused by a narrowing of the blood vessels that lead to the heart. This occurs when fatty deposits, called atherosclerosis, form along the vessel walls. If these fatty deposits become thick enough to stop blood flow, a heart attack or myocardial infarction results, which can lead to disability or death.

The risk of heart disease can be reduced through lifestyle changes — a healthy diet, physical activity and elimination of tobacco use. Risk indicators like cholesterol levels and blood pressure can be monitored to assess the effectiveness of drug treatments and lifestyle changes in reducing the chances of heart disease. Diabetes and obesity are also heart disease risks. (See “Diabetes Threatens Lives Worldwide” and “Obesity Becoming Worldwide Health Threat.”)

INTERNATIONAL COOPERATION ON RESEARCH

WHO and the Global Forum for Health Research began a cardiovascular disease research initiative in November 1998. The initiative has six research projects, including community-based interventions and clinical management programs. Researchers from Switzerland, Australia, Finland and the United States are cooperating in this effort.

WHO also sponsors a project called INTER-HEART, a global study that seeks to identify traditional and emerging heart attack risk factors, and to use that information to help develop more effective health policies.

The National Heart, Lung and Blood Institute (NHLBI), a division of the National Institutes of Health, is conducting clinical and basic research programs. Basic research is exploratory and involves experiments and studies in a laboratory setting. Clinical trials involve volunteers on whom experimental drugs and devices are tested to ascertain their efficacy and safety.

One research project involves improving the use of magnetic resonance imaging to observe the heart. NHLBI researcher Elliott McVeigh is developing strategies to overcome the two major obstacles to obtaining a good image. One problem is that the heart moves; the other is that the need for imaging often coincides with a health emergency, McVeigh told America.gov.

Imaging helps heart disease patients because it allows doctors to “to better determine which treatment is the best for each patient,” McVeigh said. “Sometimes, the treatment itself can be delivered more precisely and more effectively under direct image guidance.”

One of McVeigh’s research projects involves trying to see the shape of the scar, or “myocardial infarct,” that develops after a person has a heart attack. “The relationship of the shape of that scar to the propensity for a fatal arrhythmia at a later time is unknown. We would like to discover that relationship so that we can determine which patients need defibrillators.”

An arrhythmia, or erratic heart beat, can be treated with a defibrillator, a device that uses electrical signals to help the heart regain a healthy rhythm.

PREVENTING HEART DISEASE

Treatment and management can help address the heart disease problem, but another effective strategy for curbing this chronic illness is prevention.

In the United States, the CDC operates programs to prevent heart disease in 33 states. The programs promote heart health by educating the public, monitoring risk factors and identifying promising strategies for promoting heart-healthy interventions.

“Our research is about heart disease and stroke prevention. It begins with prevention of the risk factors themselves,” Dr. Darwin Labarthe, director of the CDC Division for Heart Disease and Stroke Prevention, told America.gov. “We are working with the World Health Organization in efforts to reduce the intake of salt to prevent high blood pressure or reduce high blood pressure.”

Prevention strategies and treatment options for heart disease are having positive effects. In the United States, the overall death rate from heart disease has decreased since the 1960s but the gains have not been consistent across demographic groups.

For instance, “[t]he gap between blacks and whites has widened in the United States,” Labarthe said. According to the CDC, in 2002, the death rate for heart disease was 30 percent higher among blacks than among whites in the United States.

“The challenges that we face today,” he said, “are to eliminate all preventable heart attacks and strokes beginning with the risk factors themselves and achieving that for all members of the population.”

Reference:

Erika Gebel. (July 24, 2008). America.gov: Heart disease a leading cause of death worldwide
global research projects seek to end preventable heart attacks, strokes.  Retrieved September 15, 2008, from
http://www.america.gov/st/health-english/2008/July/20080724175631abretnuh0.9819757.html

Other Useful Links:

Coronary Heart Disease Explained:  National Heart Lung Blood Institute
Medicine Net.com:  Coronary Artery Disease
MedLine: Heart Disease
HealthLine Heart Disease Health Channel: Physician Reviewed

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National Cancer Institute: caBIG

Diane | September 16, 2008

Resource:  National Cancer Institute – Cancer Biomedical Informatics Grid

caBIG™ stands for the cancer Biomedical Informatics Grid™. caBIG™ is an information network enabling all constituencies in the cancer community – researchers, physicians, and patients – to share data and knowledge.  The components of caBIG™ are widely applicable beyond cancer as well.

The mission of caBIG™ is to develop a truly collaborative information network that accelerates the discovery of new approaches for the detection, diagnosis, treatment, and prevention of cancer, ultimately improving patient outcomes.

The goals of caBIG™ are to:

  • Connect scientists and practitioners through a shareable and interoperable infrastructure
  • Develop standard rules and a common language to more easily share information
  • Build or adapt tools for collecting, analyzing, integrating, and disseminating information associated with cancer research and care.

Since its inception, caBIG™ has committed to the following cornerstones:

  • Federated: caBIG™ software and resources are widely distributed, interlinked, and available to everyone in the cancer research community, but institutions maintain local control over their own resources and data.
  • Open-development: caBIG™ tools and infrastructure are being developed through an open, participatory process. caBIG™ leverages existing resources whenever possible, rather than building new tools in every case.
  • Open-access:caBIG™ resources are freely obtainable by the cancer community to ensure broad data-sharing and collaboration.
  • Open-source: The caBIG™ source code is available to view, alter, and redistribute.

 

Learn concepts and terminology critical for working with caBIG™

  • “caBIG™ Essentials” Overview   (interactive, uses Adobe Flash)
    Introduces important terminology, key concepts, and describes different ways of connecting with caBIG™.

    • Alternative format:   “caBIG™ Essentials” Overview Slides
  • caBIG™ Core Concepts
    There are a number of vital concepts to both understand and connect with caBIG™. They are introduced briefly here.
  • How It Works
    Describes how caBIG™ is organized and operates.
  • caBIG™ Primer
    Complete high-level overview of the program’s vision and mission, organization, activities, and challenges.

Look up acronyms and unfamiliar terms

  • Visit the glossary: The Glossary of Acronyms and Terms has definitions for caBIG™ acronyms and common bioinformatics terms.
  • View definitions as you read:. Terms in the glossary are underlined with blue dots. Roll your mouse over the term and it’s definition will show. E.g., rest your mouse on this term – Domain Analysis Model
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Stand up to Cancer

Diane | September 14, 2008

Stand Up To Cancer

has announced an innovative approach to research designed to bring together the best and brightest investigators from leading institutions around the world. This unique initiative, which will foster scientific collaboration and accelerate the discovery of new therapies, will be administered by the American Association for Cancer Research (AACR) under the direction of a Scientific Advisory Committee led by Nobel Laureate Phillip A. Sharp, Ph.D., Institute Professor at the Massachusetts Institute of Technology and the David H. Koch Institute for Integrative Cancer Research at MIT.

>>

Streaming link to the Stand Up to Cancer Program held September 5, 2008.



Video of I’m to Young for This Foundation, founded by Matthew Zachary. He is a cancer survivor and advocate for those suffering from cancer under the age of 40.


Every day, cancer kills 1,500 Americans— one person every minute. This year, more than 550,000 Americans and six million people worldwide will succumb to this vicious disease. One out of three women and one in every two men will be diagnosed in their lifetimes. With advances in technology and research, scientists are close to pushing cancer from a disease that all too often takes lives to one people largely triumph over. This is where the end of cancer begins.

Stand Up To Cancer has announced an innovative approach to research designed to bring together the best and brightest investigators from leading institutions around the world. This unique initiative, which will foster scientific collaboration and accelerate the discovery of new therapies, will be administered by the American Association for Cancer Research (AACR) under the direction of a Scientific Advisory Committee led by Nobel Laureate Phillip A. Sharp, Ph.D., Institute Professor at the Massachusetts Institute of Technology and the David H. Koch Institute for Integrative Cancer Research at MIT.

Many leading philanthropists, organizations and corporations support the Stand Up To Cancer mission, including the Sidney Kimmel Foundation as well as Major League Baseball, Amgen, AARP, Bloomberg Philanthropies, GlaxoSmithKline, Inter-American Development Bank (IDB), Revlon, Wallis Annenberg & The Annenberg Foundation, Alliance for Global Good, Lee Jeans, New York Giants, Philips, Saks Fifth Avenue, Steve Tisch, Stonyfield Farm, The Island Def Jam Music Group and many others. In addition to ABC, CBS and NBC, SU2C major media partners include AOL, Condé Nast Media Group, eBay Inc., Facebook, Hachette Filipacchi Media U.S., Hearst Corporation, Los Angeles Times, Meredith Corporation, Paypal, The New York Times Company, Time Inc., and WebMD.

Stand Up To Cancer is a program of the Entertainment Industry Foundation (EIF), a 501(c)(3) charitable organization, and was established by a group of media, entertainment and philanthropic leaders, whose lives have all been affected by cancer in significant ways.

Stand Up To Cancer’s leadership team includes Laura Ziskin; Katie Couric; the Entertainment Industry Foundation, represented by Board of Directors Chairperson Sherry Lansing (who is also Founder of the Sherry Lansing Foundation), CEO Lisa Paulsen, and Vice President Kathleen Lobb; the Noreen Fraser Foundation and its executives Noreen Fraser (who is also a cancer survivor) and Woody Fraser, and Rusty Robertson and Sue Schwartz also of the Robertson Schwartz Agency; and nonprofit executive Ellen Ziffren, whose husband, noted L.A. attorney Ken Ziffren, played a pivotal role in bringing together the three networks for the broadcast special.

About AACR
The American Association for Cancer Research (AACR) is the oldest and largest scientific organization in the world focusing on every aspect of high-quality, innovative cancer research. Its reputation for scientific breadth and excellence attracts the premier researchers in the field. By accelerating the growth and spread of new knowledge about cancer, the AACR is on the front lines in the quest for the prevention and cure of cancer.

About the Entertainment Industry Foundation
The Entertainment Industry Foundation (EIF), the collective philanthropic organization for the television and film businesses, has distributed hundreds of millions of dollars to support programs addressing critical health, education and social issues.

About the Noreen Fraser Foundation
The Noreen Fraser Foundation utilizes film, television and web technologies to raise money for research as well as to educate and raise awareness about women’s cancers. The funds raised will be used to provide large grants to uniquely qualified cancer researchers.

 

MEDIA CONTACT:

Chet Mehta, ID – LA — 323-822-4812 cmehta@id-pr.com

Brooke Lawer, ID – NY — 212-774-6146 blawer@id-pr.com

Sherri Goldberg, ID – NY — 212-774-6151 sgoldberg@id-pr.com

 


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