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Resource:  National Institutes of Health

People with mutant forms of the gene that causes the rare disorder Gaucher disease are 5 times more likely to develop Parkinson’s disease than the general public, according to a new study. The finding may lead to new insights into developing novel therapeutic strategies for these disorders.

Parkinson’s disease is a neurodegenerative disorder that affects about 1.5 million Americans. The likelihood of developing the disorder increases with age and involves a combination of environmental risk factors and genetic susceptibility.

Earlier research by scientists at NIH’s National Human Genome Research Institute (NHGRI) and elsewhere found evidence that people with alterations in the GBA gene, which is responsible for Gaucher disease, may also be at increased risk for Parkinson’s disease. But the studies weren’t large enough to make a definitive link.

Gaucher disease arises when people inherit 2 defective copies of the GBA gene, which codes for the enzyme glucocerebrosidase. When defective, the enzyme can’t perform its normal duty of breaking down fatty molecules for disposal. The fatty molecules build up and engorge cells. Ultimately, this buildup can damage the spleen, liver, lungs, bone marrow and, in some cases, the brain.

To clarify the relationship between GBA and Parkinson’s disease, scientists from 16 research centers around the world pooled their genetic data on 5,691 Parkinson’s patients. The group included 780 Ashkenazi Jews, a population in which a particular type of Gaucher disease is more prevalent. These data were matched against a control group of 4,898 unaffected volunteers, including 387 Ashkenazi Jews. The study was supported in part by NHGRI and several other NIH components.

In the October 22, 2009, issue of the New England Journal of Medicine, the scientists reported that more than 3% of the Parkinson’s patients—but only 0.6% of controls—had at least 1 of 2 common GBA alterations. Among Ashkenazi subjects, 15.3% of those with Parkinson’s disease carried one of these GBA alterations compared to 3.4% of controls.

In addition to screening for the 2 common alterations, the entire GBA gene was sequenced in a subset of non-Ashkenazi volunteers—1,883 with Parkinson’s disease and 1,611 controls. This more thorough analysis linked several more mutations to Parkinson’s disease. Overall, 7% of the Parkinson’s patients were found to have the GBA alterations. Those Parkinson’s patients with the GBA alterations also had an earlier disease onset.

“This analysis illustrates how studying a rare but important disorder, like Gaucher disease, can provide powerful clues about more common disorders, such as Parkinson’s disease,” said NHGRI Scientific Director Dr. Eric Green. “Understanding the genetic basis of rare conditions can thus provide insights into normal cellular and biological processes, which in turn may lead to improved diagnostic and therapeutic strategies.”

These mutations are among the most significant risk factors found to date for Parkinson’s disease. However, many GBA mutation carriers, as well as patients with Gaucher disease, never develop Parkinson’s disease. Other risk factors are clearly involved in the development of the disease.

Reference:
National Institutes of Science (October 26, 2009) Rare disease gene linked to Parkinson’s disease.  Retrieved October 26, 2009 from http://www.nih.gov/researchmatters/october2009/10262009parkinsons.htm